Lesions in Porcine Liver Tissues Created by Continuous High Intensity Ultrasound Exposures in Vitro

doi:10.1088/0256-307X/30/2/024302

Chin. Phys. Lett.

2013, Vol. 30

Issue (2): 024302 DOI: 10.1088/0256-307X/30/2/024302

FUNDAMENTAL AREAS OF PHENOMENOLOGY(INCLUDING APPLICATIONS)

Lesions in Porcine Liver Tissues Created by Continuous High Intensity Ultrasound Exposures in Vitro

ZHANG Zhe, CHEN Tao, ZHANG Dong^**

Key Laboratory of Modern Acoustics (Ministry of Education), Nanjing University, Nanjing 210093

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ZHANG Zhe, CHEN Tao, ZHANG Dong 2013 Chin. Phys. Lett. 30 024302

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Abstract Lesions in porcine liver tissues created by continuous high intensity focused ultrasound (HIFU) exposures in vitro are theoretically and experimentally investigated, with the transmitter moving along a linear path at a fixed speed. Numerical simulations of the lesion formation are performed based on the Khokhlov–Zabolotskaya–Kuznetov equation and the bio-heat equation. In order to verify the theoretical predictions, experiments are performed in the one-dimensional scanning mode to measure the cross-sectional area of lesions created in the in vitro porcine liver exposed to 1.01-MHz HIFU pulses with the acoustic power of 70 W. The results indicate that, compared to the traditional discrete treatment protocol, the application of a continuous scanning model can create more uniform lesions in tissues and significantly reduces the total treatment time from 47 s to 30 s.

Received: 08 October 2012 Published: 02 March 2013

PACS:	43.25 +y
	43.80.+p	(Bioacoustics)

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https://cpl.iphy.ac.cn/10.1088/0256-307X/30/2/024302 OR https://cpl.iphy.ac.cn/Y2013/V30/I2/024302

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[1] Leslie T A and Kennedy J E 2006 Ultrasound Q 22 263
[2] Jolesz F A et al 2005 Magn. Reson Imaging Clinic North Am. 13 545
[3] Kennedy J E et al 2002 Ultrasonics 42 931
[4] Wu F et al 2002 Ultrasound Med. Biol. 28 535
[5] Wu F et al 2005 Radiology 235 659
[6] ter Haar G and Coussios C 2007 Int. J. Hyperthermia 23 89
[7] Wu F et al 2004 Ultrasound Med. Biol. 30 245
[8] Fan T B et al 2009 Chin. Phys. Lett. 26 084302
[9] Khokhlova V A et al 2006 J. Acoust. Soc. Am. 119 1834
[10] Meaney P M, Cahill M D and ter Haar G 2000 Ultrasound Med. Biol. 26 441
[11] Pennes H 1948 J. Appl. Phys. 1 93
[12] Vaezy S et al 2001 Annu. Rev. Biomed. Eng. 3 375
[13] Tu J et al 2012 Appl. Phys. Lett. 101 124102
[14] Sapareto S A and Dewey W C 1984 Int. J. Radiat. Oncol. Biol. Phys. 10 787
[15] Canney M S et al 2008 J. Acoust. Soc. Am. 124 2406

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