| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants |
LIU Yu-Zhi1, AN Hai-Long1, ZHANG Su-Hua1, YU Hui1, ZHAN Yong1, ZHANG Hai-Lin2 |
| 1Institute of Biophysics, Hebei University of Technology, Tianjin 300130 2Departments of Pharmacology, Hebei Medical University, Shijiazhuang 050017 |
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| Cite this article: |
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LIU Yu-Zhi, AN Hai-Long, ZHANG Su-Hua et al 2010 Chin. Phys. Lett. 27 088701 |
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Abstract We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K+ channels, determine the selectivity of the channel.
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| Keywords:
87.16.Uv
05.10.Gg
31.15.Ew
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Received: 13 May 2010
Published: 28 July 2010
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