| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Effect of Phosphate on the Self-Assembly of Peptide EMK16-II |
| ZOU Da-Wei, TIE Zuo-Xiu, QIN Meng, LU Chun-Mei, WANG Wei |
| National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093 |
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| Cite this article: |
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ZOU Da-Wei, TIE Zuo-Xiu, QIN Meng et al 2009 Chin. Phys. Lett. 26 088103 |
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Abstract The ionic-complementary peptide EMK16-II is used to investigate the effects of hydrophobic and electrostatic interactions on the self-assembling process by atomic force microscopy and circular dichroism spectra. It is found that the increase of hydrophobicity of the peptides promotes the aggregation of fibrils in pure water. The effects of phosphate with different concentrations on electrostatic interactions are also investigated. It is found that the self-assembling process is enhanced at a low concentration of phosphate and more ordered fibrillar aggregates are formed. When the concentration of phosphate increases to a certain value (9mM), only a few fibrils are found to be formed. No fibrils but amorphous aggregates exist when the concentration further increases. A physical interpretation is presented such that one divalent anion can interact with two
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| Keywords:
81.16.Dn
87.14.Ef
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Received: 21 April 2009
Published: 30 July 2009
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