| CROSS-DISCIPLINARY PHYSICS AND RELATED AREAS OF SCIENCE AND TECHNOLOGY |
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Robust and Adaptive MicroRNA-Mediated Incoherent Feedforward Motifs |
| XU Feng-Dan1,2, LIU Zeng-Rong1,2, ZHANG Zhi-Yong1,2, SHEN Jian-Wei 1,2 |
| 1Department of Mathematics, Shanghai University, Shanghai 2004442Institute of Systems Biology, Shanghai University, Shanghai 200444 |
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| Cite this article: |
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XU Feng-Dan, LIU Zeng-Rong, ZHANG Zhi-Yong et al 2009 Chin. Phys. Lett. 26 028701 |
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Abstract We integrate transcriptional and post-transcriptional regulation into microRNA-mediated incoherent feedforward motifs and analyse their dynamical behaviour and functions. The analysis show that the behaviour of the system is almost uninfluenced by the varying input in certain ranges and by introducing of delay and noise. The results indicate that microRNA-mediated incoherent feedforward motifs greatly enhance the robustness of gene regulation.
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| Keywords:
87.15.Aa
87.16.Yc
87.80.Vt
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Received: 01 September 2008
Published: 20 January 2009
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